Health care providers can use alcohol screening and brief intervention (ASBI) before prescribing opioids to reduce opioid overdose deaths involving alcohol. Alcohol was involved in 22% of deaths caused by opioid pain relievers and 18% of emergency department visits related to the misuse of opioid pain relievers in the United States in 2010. Screening and brief intervention for excessive alcohol use (ASBI) is an effective clinical prevention strategy for reducing excessive drinking, but it is underused in clinical settings. The purpose of this 4 page document is to familiarize health departments and health care providers with ASBI, discuss its usefulness for helping excessive drinkers who may be prescribed an opioid pain reliever to drink less or stop drinking altogether while using opioid medications, and assist state health departments in supporting health systems and other community partners carrying out ASBI in various settings as a part of routine practice. A reference for routinely implementing ASBI in health systems is also included.